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The heterogeneity of Parkinson's disease

Clinical and prognostic implications

Department of Neurology, Baylor College of Medicine, Houston, TX.

In 334 patients with idiopathic Parkinson's disease, deterioration in mental status paralleled severity of bradykinesia, postural instability, and gait difficulty. Tremor was relatively independent of the other cardinal signs and was associated with relative preservation of mental status, earlier age at onset, family history of parkinsonism, and more favorable prognosis. There seem to be at least two Parkinson's subgroups: one with postural instability and gait difficulty and another with tremor as the dominant feature.

Address correspondence and reprint requests to Dr. Jankovic, Department of Neurology. Baylor College of Medicine, Texas Medical Center, Houston. TX 77030.

Presented in part at the 35th annual meeting of the American Academy of Neurology, San Diego, CA, April 1983.

Accepted for publication July 30, 1984.

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