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Reversal of sleep disturbance in Parkinson's disease by antiparkinsonian therapy

a preliminary study

SWDC-Loewenstein Center, Raanana, Israel, and the Mount Sinai School of Medieine, New York, NY.

In a previous study, the sleep pattern in Parkinson's disease patients was found to be altered. The disturbance consisted of a "light fragmented sleep pattern" with increased muscle activity. Using a combined polysomnographic and electromyographic recording technique, we found that a reversal of the light fragmented sleep pattern and normalization of muscle activity during sleep occurred after clinical improvement with dopaminergic treatment. The effect of dopaminergic treatment on sleep disturbance was analyzed. There is an intimate relationship between sleep pattern and the normalization of sleep muscle activity produced by dopaminergic agents.

Address correspondence and reprint requests to Dr. Askenasy, Director of Sleep Wake Disorders Center, Loewenstein Rehabilitation Center, PO Box 3.43 100 Raanana. Israel.

Presented in part at the annual National Meeting of the Israel and Italian Neurological Society, Israel, November 1983.

Accepted for publication August 9, 1984.

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