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Acetylcholine receptor antibody production by bone marrow cells in a patient with myasthenia gravis

First Department of Surgery, Osaka University Medical School, Osaka, Japan.

We briefly report antiacetylcholine receptor antibody production by cultured bone marrow cells (4.9 ± 0.9 fmol/10⁶ cells/wk, mean ± SD) in a 65-year-old man with myasthenia gravis without thymoma. Lymphocytes from peripheral blood, thymus, and lymph nodes produced less antibody (1.8 ± 0.1, 0.9 ± 0.3, and 1.0 ± 0.4, respectively). The thymus was involuted, and the effect of thymectomy was doubtful 6 months postoperatively.

Address correspondence and reprint requests to Dr. Fujii, First Department of Surgery, Osaka University Medical School. 1–1–50 Fukushima, Osaka 553, Japan.

Supported by a grant from the Ministry of Education of Japan.

Accepted for publication August 6, 1984.