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NEUROLOGY 1985;35:579
© 1985 American Academy of Neurology

Amantadine in the treatment of refractory epilepsy in childhood

An open trial in 10 patients W. Donald Shields, MD, Jean L. Lake, MD and Harry T. Chugani, MD

Departments of Neurology and Pediatrics, UCLA School of Medicine, Los Angeles, CA.

Amantadine HCl was given to 10 children with medically reffactory seizures; other anticonvulsant medications were continued unchanged through the 12- to 16-week trial. Several patients noted improvement in control of myoclonic or atypical absence seizures. Tonic seizures were controlled in one patient, but worsened in another. Tonicclonic and atonic seizures remained unchanged or worsened. Amantadine may be useful as an adjunctive anticonvulsant in some children with refractory atypical absence or myoclonic seizures.

Address correspondence and reprint requests to Dr. Shields, Chief, Division of Pediatric Neurology, UCLA School of Medicine, Los Angeles, CA 90024.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, San Diego. CA, April 1983.

Accepted for publication July 30, 1984.

This article has been cited by other articles:

				W. E. Dodson and B. F.D. Bourgeois Pharmacology and Therapeutic Aspects of Antiepileptic Drugs in Pediatrics J Child Neurol, October 1, 1994; 9(2_suppl): 281 - 287. [Abstract] [PDF]