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NEUROLOGY 1985;35:581
© 1985 American Academy of Neurology

Guillain-Barré syndrome in Larimer County, Colorado

A high-incidc, wce area

Jonathan E. Kaplan, MD, Paul J. Poduska, RM (AAM), Gerald C. McIntosh, MD, Richard S. Hopkins, MD, Stanley W. Ferguson, PhD and Lawrence B. Schonberger, MD

Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta, GA; the Poudre Valley Hospital, Fort Collins, CO; and the Colorado Department of Health, Denver, CO.

During the period 1981–1983, 19 cases of Guillain-Barré syndrome (GBS) occurred in residents of Larimer County, Colorado, for an incidence of 4.0 cases per 100,000 population per year, compared with 1.2 cases per 100,000 per year in 1975–1980 0, < 0.05). The higher incidence of GBS in 1981–1983 may represent an unusual chance occurrence, since no patient characteristics or predisposing events could be found to explain the increase. Nevertheless, the findings demonstrate that over a period of as long as 3 years, the crude average annual incidence of GBS in a large, well-defined population may exceed by twofold the upper limit of the previously reported range (0.6 to 1.9 cases per 100,000 per year).

Address correspondence and reprint requests to Dr. Kaplan, Division of Viral Diseases, Bldg. 6, Room 127, Centers for Disease Control, Atlanta, GA 30333.

Accepted for publication August 14, 1984.




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