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Relapsing ophthalmoparesissensory neuropathy syndrome

Departments of Neurology and Pathology (Neuropathology) (Drs. Kaplan and Schaumhurg), Albert Einstein College of Medicine, Bronx, NY, and the Department of Neurology (Dr. Sumner), University of Pennsylvania, Philadelphia.

We studied two patients with recurrent sensory neuropathy and weakness of extraocular muscles. There was electrophysiologic evidence of multifocal demyelination of sensory nerves, with relative sparing of somatic motor nerves. Sural nerve biopsy in one patient showed segmental demyelination. We believe that these patients had an unusual form of inflammatory polyneuropathy—possibly a relapsing variant of the Miller-Fisher syndrome of acute idiopathic polyneuritis.

Address correspondence and reprint requests to Dr. Schaumburg, Rose F. Kennedy Center, Room 519, Albert Einstein College of Medìcine, 1300 Morris Park Avenue, Bronx, NY 10461.

Supported in part by NINCDS grants OH-00535, OH-00851, and NS19611.

Accepted for publication August 6, 1984.