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Thymectomy in multiple sclerosis

A 3-year follow-up

Departments of Neurology and Neurosurgery (Neurology) (Drs. Trotter, Clifford. and Montgomery), and the Department of Surgery (Dr. Ferguson), Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO.

We studied 34 MS patients who were treated experimentally by thymectomy with or without 1 year of azathioprine therapy. After 3 years, there was no evidence of benefit. Relapsing-remitting patients had done as well or better clinically than controls, and the chronic progressive group did less well statistically than controls.

Address correspondence and reprint requests to Dr. Trotter, Department of Neurirlogy and Neurosurgery (Neurology), Box 8111, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110.

Supported by the Kroc Foundation while Dr. Trotter was a recipient of the NIH Teacher-Investigator award NS-00221. The studies were performed in the Washington University School of Medicine Clinical Research Center supported by grant PHS-RR-36.

Accepted for publication October 26, 1984.