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NEUROLOGY 1985;35:1108
© 1985 American Academy of Neurology

Preservation of voluntary saccades after intracarotid injection of barbiturate

R. P. Lesser, R. J. Leigh, D. S. Dinner, H. Luders, H. H. Morris, R. L. Tomsak and K. I. Lockwood

Department of Neurology and 'Ophthalmology (Drs. Lesser, Dinner, Lüders, Morris, Lockwood, and *Tomsak), Cleveland Clinic Foundation; and the Neurology Service, Cleveland Veterans Administration Medical Center and Department of Neurology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH (Dr. Leigh). Dr. Lockwood is now with the Department of Neurology, University of Texas School of Medicine, San Antonio, TX.

We studied voluntary saccades in 44 patients undergoing Wada testing before surgery for intractable epilepsy. After intracarotid injection of barbiturate, and while they were hemiplegic, patients could still make voluntary saccades toward or away from the side of injection. Sustained ipsiversive deviation of gaze was not noted. Saccades made away from the side of injection were slower than ipsilateral saccades in only 3 of 10 tests. These data support the hypothesis of parallel, independent pathways from the frontal eye fields and from the superior colliculi to the brainstem reticular nuclei that generate saccades.

Address correspondence and reprint requests to Dr. Lesser, Department of Neurology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44106.

Dr. Leigh is supported by the Veterans Administration and the Evenor Armington Fund.

Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.

Accepted for publication November 30, 1984.






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