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NEUROLOGY 1985;35:1176
© 1985 American Academy of Neurology

Viral antibodies in twins with multiple sclerosis

J. L. Woyciechowska, J. Dambrozia, P. Leinikki, C. Shekarchi, W. Wallen, J. Sever, H. McFarland and D. McFarlin

National Institutes of Health, Infectious Diseases Branch, IRP, NINCDS (Drs. Woyciechowska. Wallen. and Sever), Office of Biometry and Field Studies, NINCDS (Dr. Dambrozia), and Neuroimmunology Branch, IRP, NINCDS (Drs. McFarland and McFarlin). Bethesda, MD; the Department of Biomedical Science (Dr. Leinikki), University of Tampere, Tampere 10, Finland and Microbiological Associates, Inc. (Dr. Shekarchi), Bethesda, MD.

Viral antibodies to measles, rubella, corona, vaccinia, and mumps viruses in serum and CSF (and to Epstein-Barr virus in serum only) were studied in 24 twin pairs, both discordant and concordant for clinical MS. In pairs, CSF antibody titers for rubella in MS monozygotic and dizygotic twins and for vaccinia in dizygotic twins were higher than for unaffected twins. Increased CSF titers among MS twins existed for measles, rubella, and vaccinia when pairing was ignored. Among MS twins, serum rubella and measles and CSF measles antibody titers, and CSF:serum ratios for measles virus, were higher in those who were DW, positive.

Address correspondence and reprint requests to Dr. Woyciechowska, Department of Health & Human Services, Public Health Service, National Institutes of Health. Bldg. 36, Rm. 5D06, Bethesda. MD 20205.

Accepted for publication November 16, 1984.




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