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NEUROLOGY 1985;35:1299
© 1985 American Academy of Neurology

The metabolic consequences of experimental intraventricular hemorrhage

Michael R. Pranzatelli, MD and David A. Stumpf, MD, PhD

From the Departments of Neurology and Pediatrics, School of Medicine, The University of Colorado Health Sciences Center. Denver, CO.

Experimental intraventricular hemorrhage was produced by injection of autologous fresh blood (0.25 ml/kg) or artificial CSF into the right lateral ventricle of 24 dogs. A transient ventricular fluid acidosis (pH drop to 7.09) was accompanied by increased lactate, pyruvate, ammonia, and Pco2, and decreased bicarbonate and glucose. High lactate/pyruvate ratios were the most persistent abnormality. The control group, which received intraventricular artificial CSF, developed minimal ventricular fluid acidosis (pH 7.26). Lumbar CSF and venous blood acid-base parameters did not change. Simultaneous cisternal samples obtained from some of the animals reflected similar metabolic abnormalities of lesser magnitude. Intraventricular injection of sodium bicarbonate normalized the pH in four animals.

Address correspondence and reprint requests to Dr. Stumpf, Director of Pediatric Neurology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, II, 60614.

Supported by a Clinical Research Grant from the Center for Investigative Pediatrics, Denver, CO, and NIH National Research Service Award. Dr. Pranzatelli presented this work as the Junior Membership Research Award recipient at the Child Neurology Society Annual Meeting in 1983.

Accepted for publication January 4, 1985.






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