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Effect of TRH analogs on neurologic recovery after experimental spinal trauma

From the Neurobiology Research Unit, Uniformed Services University of the Health Sciences (Drs. Faden and Jacobs), Bethesda, MD; the Department of Neurology (Dr. Faden), University of California, and the Center for Neural Injury, San Francisco Veterans Administration Medical Center, San Francisco, CA.

Effects of two stable TRH analogs were compared after experimental spinal trauma in cats. CG3509, which has a substitution at the amino-terminus of the peptide, improved neurologic recovery; MK771, which has modifications at both ends of the tripeptide, was ineffective. These findings indicate that TRH analogs may be of use in spinal cord injury, and suggest that the C-terminal amino acid may be critical for the beneficial effects of TRH or TRH-analogs in CNS injury.

Address correspondence and reprint requests to Dr. Faden, Chief, Neurology Service (127). San Francisco Veterans Administration Medical Center. 4150 Clement Street, San Francisco, CA 94121.

Supported in part by the Office of Naval Research (Contract No. N0001482WR20257) and USAMRDC (Contract No. 01120–82).

Accepted for publication December 11, 1984.