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Reye's syndrome

Incidence and time trends in Olmsted County, MN, 1950–1981

From the Department of Medical Statistics and Epidemiology, Mayo Clinic and Foundation, Rochester, MN (Dr. Kurland); the Gertrude H. Sergievsky Center, Columbia University, New York, NY (Drs. Nico1osi and Hauser); and the Mario Negri Institute, Milan, Italy (Dr. Beghi).

Incidence and time trends of Reye's syndrome have been determined in Olmsted County, MN, using the facilities of the Rochester Epidemiology Program Project at Mayo Clinic. Incidence rates in individuals under 18 years of age were 1.1 per 100,000 person-years in the 1970–75 time interval and 1.7 in the 1976–81 interval. Failure to identify any case in the earliest time interval yields a rate of zero, and an incidence higher than 0.6 per 100,000 can be excluded with 95% probability. This finding is consistent with an increasing incidence over time in this community and does not exclude the possibility that Reye's syndrome did not exist in Olmsted County before 1970.

Address correspondence and reprint requests to Dr. Hauser, G.H. Sergievsky Center, 630 W. 168th St., New York, NY 10032.

Supported in part by Research Grants NS-16308, NS 17750, and AM-30582 from the National Institutes of Health, Public Health Service, Bethesda, MD.

Accepted for publication December 17, 1984.