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NEUROLOGY 1985;35:1348
© 1985 American Academy of Neurology

Treatment of Alzheimer's disease with a synthetic ACTH 4–9 analog

H. Soininen, MD, T. Koskinen, MD, E.-L. Helkala, BA, R. Pigache, MD and P.J. Riekkinen, MD

From the Department of Neurology (Drs. Soininen, Helkala, and Riekkinen), University Central Hospital of Kuopio, Harjamaki Mental Hospital (Dr. Koskinen), Kuopio, Finland, and Organon (Dr. Pigache), Oss, The Netherlands.

The synthetic ACTH 4–9 analog, Org 2766, was administered to 77 Alzheimer's patients for 6 months in a double-blind, placebo-controlled study. Although Org 2766 was tolerated well, no significant effect of Org 2766 could be demonstrated in terms of rating scales or cognitive functions.

Address correspondence and reprint requests to Dr. Soininen, Department of Neurology, University Central Hospital of Kuopio, SF-70210 Kuopio, Finland.

Accepted for publication January 4, 1985.




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