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Neurosyphilis in the antibiotic era

From the Department of Neurology (Dr. Burke) and Division of Infectious Diseases, Department of Internal Medicine (Dr. Schaberg), University of Michigan, Ann Arbor, MI.

Among 30 patients with neurosyphilis diagnosed between 1970 and 1981, 43% had symptoms attributable to neurosyphilis, 43% had unrelated symptoms, and 14% were asymptomatic. Serum VDRL was positive in 86%, and the CSF VDRL was positive in 53%. Meningovascular and vascular syphilis were relatively more common than in the prepenicillin era; tabes dorsalis and general paresis were unchanged in relative frequency.

Address correspondence and reprint requests to Dr. Burke, Department of Neurology, Albert Einstein Medical Center, Northern Division, York and Tabor Roads, Philadelphia, PA 19141.

Accepted for publication January 4, 1985.

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