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NEUROLOGY 1986;36:106
© 1986 American Academy of Neurology

Increased plasma uric acid after exercise in muscle phosphofructokinase deficiency

Norio Kono, Ikuo Mineo, Takao Shimizu, Naoko Hara, Yuya Yamada, Kyohei Nonaka and Seiichiro Tarui

Second Department of Internal Medicine. Osaka University Medical School, Fukushima-ku, Osaka, Japan.

Type VII glycogenosis (muscle phosphofructokinase deficiency) is attended by hyperuricemia and hyperuricosuria. In one patient, we found that exercise on a bicycle ergometer increased plasma uric acid, inosine, and hypoxanthine levels. Forearm exercise also markedly increased venous inosine, hypoxanthine, and ammonia in the exercising arm of two patients. Exaggerated release of precursors for uric acid synthesis from exercising muscle may be related to the hyperuricemia.

Address correspondence and reprint requests to Dr. Kono, The Second Department of Internal Medicine, Osaka University Medical School, Fukushima-ku, Osaka, Japan 553.

Supported in part by Grants-in-Aids for Scientific Research (nos. 59480214, 59480255, 59570484, and 59870040) and for Special Project Research from the Ministry of Education, Science and Culture of Japan; and Basic Research Grant from the Muscular Dystrophy Association of the United States.

Accepted for publication April 18, 1985.




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