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NEUROLOGY 1986;36:111
© 1986 American Academy of Neurology

Krabbe disease

Specific MRI and CT findings

Tallie Z. Baram, MD, PhD, Arnold M. Goldman, MD and Alan K. Percy, MD

Departments of Pediatrics and Neurology (Drs. Baram and Percy), Baylor College of Medicine and the Pediatric Neurology Service, Texas Children's Hospital; and NMR Associates-Kirby (Dr. Goldman), Houston, TX.

In three patients with Krabbe disease (galactosylceramide lipidosis), CT and MRI patterns progressed with the evolution of the disease. At first, discrete and symmetric dense areas on CT were found in deep gray matter of hemispheres and brainstem, and also in periventricular and capsular white matter. MRI showed decreased T1 values with normal or slightly decreased T2 values in those areas and large symmetric "plaque-like" lesions with high T1 and T2 values in white matter of the centrum semiovale. Later, both CT and MRI revealed diffuse reduction in gray matter and, more profoundly, in white matter mass. These findings may alert clinicians to the possibility of Krabbe disease in infants with progressive encephalopathy.

Address correspondence and reprint requests to Dr. Percy, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

Supported by funds from Texas Children's Hospital, Houston, TX.

Accepted for publication May 8, 1985.




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