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Different effects of 4-aminopyridine on sensory and motor fibers

Pathogenesis of paresthesias

Department of Neurology, Stanford University School of Medicine, Veterans Administration Medical Center, Palo Alto, CA.

Mammalian motor and sensory fibers respond differently to the potassium channel-blocking agent, 4-aminopyridine (4-AP). The action potentials of the motor fibers increase in duration after 4-AP, while the sensory fibers respond with bursts of action potentials after a single stimulus. These differences may account for the paresthesias reported by patients with multiple sclerosis following treatment with 4-AP.

Address correspondence and reprint requests to Dr. Kocsis, Department of Neurology (127), Veterans Administration Medical Center, 3801 Miranda Avenue, Palo Alto, CA 94304.

Supported in part by grants from the National Institutes of Health, the National Multiple Sclerosis Society, and the Folger Foundation, and by the Medical Research Service, Veterans Administration.

Accepted for publication May 8, 1985.

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