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Incidence of multiple sclerosis in Macomer, Sardinia, 1912–1981

Onset of the disease after 1950

Neurological Clinic of the University of Sassari (Drs. Rosati, Aiello, Pirastru, Becciu, Demontis, Mannu, and Zoccheddu) and the Neurological Clinic of the University of Ferrara (Dr. Granieri), Italy.

Intensive search of all cases of MS occurring in the Sardinian commune of Macomer since 1912 indicated that MS was absent up to the early 1950s. All 13 ascertained cases had clinical onset in the years 1952–1981. During this period, the average annual incidence was 4.8 per 100,000; the highest incidence was found in the period 1957–1961, slowly decreasing up to 1981. MS was probably introduced after 1945, when the centuries-old isolation of Macomer ended and the native population came into contact with individuals from high-and medium-risk areas.

Address correspondence and reprint requests to Dr. Rosati, Clinica Neurologica dell Università, viale S. Pietro 10, 07100 Sassari, Italy.

Supported by the Ministero della Pubblica Istruzione d'Italia and the Assessorato Igiene e Sanità della Regione Autonoma della Sardegna.

Presented in part at the International Workshop on Multiple Sclerosis, Erice, Italy, August 28-September 2, 1983, and at the Twenty-third Congress of the Italian Society of Neurology, Parma, Italy, October 20–22, 1983.

Accepted for publication April 30, 1985.

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