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Dent Neurologic Institute, Millard Fillmore Hospital (Drs. Jacobs, W.R. Kinkel, Polachini, and R.P. Kinkel), and the State University of New York, School of Medicine at Buffalo, Departments of Neurology and Physiology (Neurobiology) (Dr. Jacobs) and Departments of Neurology and Anatomy (Dr Kinkel), Buffalo, NY.
Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The appearance and locations of lesions identified by NMR were similar to those of autopsy studies of MS and may be relatively specific for this disease. Some lesions identified by CT disappeared during serial examinations, but lesions identified by NMR did not resolve over time. Seventy-five percent of the lesions were clinically "silent"; only 5% were definitely related to the clinical symptoms and signs. All of those lesions were located in the brainstem or cerebellar peduncles and were identified by NMR, but missed by CT.
Address correspondence and reprint requests to Dr. Jacobs, Dent Neurologic Institute, 3 Gates Circle, Buffalo, NY 14209.
Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.
Supported in part by grants from the USPHS, NINCDS (NS19649); the Baird, Buffalo, James H. Cummings, and Dent Family Foundations; and the Delaware North, Higgins Construction, and Niagara Frontier Services Companies, all of Buffalo, NY; and Technicare Corporation of Cleveland, OH.
Accepted for publication April 30, 1985.
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