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Clinical Epilepsy Section, Medical Neurology Branch (Drs. Theodore and Porter), the Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. DiChiro, Fishbein, and Brooks), NINCDS, IRP, NIH; and the Nuclear Medicine Department (Dr. Margolin), Clinical Center, NIH, Bethesda, MD.
We studied the effect of barbiturates on local cerebral glucose metabolism by performing positron emission scans before and after withdrawal of phenobarbital or primidone. The postwithdrawal scan showed a significant increase (mean, 37%) in seven of eight cortical regions tested. Patients who had serial scans without a drug change showed a nonsignificant tendency for metabolic rates to go down on the second scan (mean decrease, 7%). Addition or deletion of a single drug other than barbiturate did not change metabolic rates on repeat scans. The depression in cerebral glucose metabolic rate due to phenobarbital, if confirmed, may have bearing on the adverse neuropsychological effects of the drug.
Address correspondence and reprint requests to Dr. Theodore, Clinical Epilepsy Section, Medical Neurology Branch, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Building 10-Room 5N248, 9000 Rockville Pike, Bethesda, MD 20205.
Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.
Accepted for publication April 18, 1985.
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