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Myasthenia gravis in identical twins

Neurology Department, Richmond Hospital, Dublin, Ireland.

The literature records myasthenia gravis in five sets of monozygous twins; we report another pair in which monozygosity was determined by blood group analysis, HLA typing, and mixed lymphocyte culture. Acetylcholine receptor antibodies were strongly positive in both twins. Poor response to anticho-linergic medication and thymectomy necessitates low-dose daily maintenance prednisone for a normal life-style. The probability of myasthenia developing in the unaffected monozygotic twin is highest soon after diagnosis in the proband and an unaffected twin should be followed indefinitely.

Address correspondence and reprint requests to Dr. S.F. Murphy, Neurology Department, Richmond Hospital, Dublin 7, Ireland.

Accepted for publication May 17, 1985.

This article has been cited by other articles:

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