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NEUROLOGY 1986;36:89
© 1986 American Academy of Neurology

CSF cyclic nucleotides and somatostatin in Parkinson's disease

Ladislav Volicer, MD, PhD, M. Flint Beal, MD, Lorne K. Direnfeld, MD, Judith K. Marquis, PhD and Martin L. Albert, MD

Geriatric Research Education Clinical Center, E.N. Rogers Memorial Veterans Hospital, Bedford, MA; and the Boston Veterans Administration Medical Center; the Departments of Pharmacology and Neurology, Boston University Medical School; Massachusetts General Hospital; and Harvard Medical School, Boston, MA.

Concentrations of cyclic adenosine 3',5' monophosphate (cAMP) were significantly lower in parkinsonian patients than in controls, but concentrations of guanosine 3',5' monophosphate (cGMP) were not altered. Both cAMP and cGMP levels were lower in patients with more severe symptoms on the left side of the body. Somatostatin-like immunoreactivity (SLI) was similar in parkinsonian patients and controls. Both cAMP and SLI were significantly related to acetylcholinesterase activity.

Address correspondence and reprint requests to Dr. Volicer, V.A. Hospital, GRECC, 200 Springs Rd, Bedford, MA 01730.

This work was supported by the Veterans Administration, by an NIA Clinical Investigator Award (to L.K.D.) and a grant to J.K.M. from Che Cambridge Center for Brain Sciences and Metabolism Charitable Trust.

Presented in part at the thirty-sixth annual meeting of the American Academy of Neurology, Boston, MA, April 1984.

Accepted for publication May 10, 1985.






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