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NEUROLOGY 1986;36:98
© 1986 American Academy of Neurology

Double-blind study of oral {gamma}-vinyl GABA in the treatment of dystonia

F. Carella, MD, F. Girotti, MD, G. Scigliano, MD, T. Caraceni, MD, A. M. Joder-Ohlenbusch and P. J. Schechter, MD, PhD

Istituto Neurologico "C. Besta" (Drs. Carella, Girotti, Scigliano, and Caraceni), Milano, Italy, and Merrell Dow Research Institute (Madame Joder-Ohlenbusch and Dr. Schechter), Strasbourg, France.

Six patients with different forms of dystonia were treated with {gamma}-vinyl GABA, a specific enzyme-activated inhibitor of GABA-trans-aminase, in a double-blind, placebo-controlled crossover study, {gamma}-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.

Address correspondence and reprint requests to Dr. Caraceni, Istituto Neurologico "C. Besta," Via Celoria n. 11, 120133 Milano, Italy.

Accepted for publication May 17, 1985.






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