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NEUROLOGY 1986;36:1380
© 1986 American Academy of Neurology

Benzodiazepine receptor binding is not altered in human epileptogenic cortical foci

Allan Sherwin, Elizabeth Matthew, Manon Blain and Diane Guévremont

Montreal Neurological Institute, and the Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

We measured benzodiazepine binding in cortical tissues from 13 patients with partial seizures. No differences in receptor density (Bmax) or affinity (Kd) were observed when epileptic foci were compared with nonspiking cortex.

Address correspondence and reprint requests to Dr. Sherwin, Montreal Neurological Institute, 3801 University Street. Montreal, Quebec, Canada H3A 2B4.

Supported by the Medical Research Council of Canada.

Accepted for publication February 7, 1986.






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