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Multiple sclerosis

Increased expression of interleukin-2 receptors on lymphocytes

Academic Unit of Neuroscience (Drs. Selmaj, Alam, Perkin, and Rose). Charing Cross and Westminster Medical School, and the Clinical Immunology Division (Dr. Plater-Zyberk, Mr. Rockett, and Prof. Maini), Kennedy Institute of Rheumatology, London, UK.

The percentage of interleukin-2 receptor-positive peripheral blood lymphocytes in MS patients was significantly higher in acute relapse than in remission or in controls. After stimulation by phytohemagglutinin, the expression of interleukin-2 receptor on peripheral blood lymphocytes of MS patients was within the range of healthy controls, implying no general impairment of receptor expression. These results confirm other evidence that there is a small population of activated T lymphocytes in acute relapse of MS.

Address correspondence and reprint requests to Dr. Plater-Zyberk, Clinical Immunology Division, Kennedy Institute of Rheumatology, 6 Bute Gardens, London W6 7DW, UK.

We thank the British Council for financial support in the form of a British Council Fellowship to Dr. Selmaj.

Accepted for publication February 16, 1986.

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