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NEUROLOGY 1986;36:1395
© 1986 American Academy of Neurology

Acute pure sensory paraneoplastic neuropathy with perivascular endoneurial inflammation

Ultrastructural study of capillary walls

J. M. Vallat, MD, M. J. Leboutet, MD, J. Hugon, MD, A. Loubet, MD, M. Lubeau, MD and C. Fressinaud, MD

Departments of Neurology (Drs. Vallat, Hugon, Lubeau, and Fressinaud) and Pathology (Drs. Leboutet and Loubet), University Hospital, Limoges, France.

We studied a patient with epidermoid carcinoma of the lung (treated surgically 1 year earlier) and an acute symmetric pure sensory neuropathy that regressed almost completely within 1 month. Superficial peroneal nerve biopsy 15 days after onset showed evidence of demyelination with perivascular endoneurial inflammation. On ultrastructural examination, lymphocytes were seen passing through endothelial cells of endoneurial capillaries.

Address correspondence and reprint requests to Dr. Vallat, Department of Neurology, University Hospital, 87 042, Limoges, France.

Accepted for publication February 7, 1986.






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