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Department of Neurology, Columbia University College of Physicians and Surgeons; Neurological Institute of Presbyterian Hospital: H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases; and the General Clinical Research Center of the Columbia-Presbyterian Medical Center.
In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.
Address correspondence and reprint requests to Dr. Shy, Department of Neurology, Jefferson Medical College, 1025 Walnut Street, Philadelphia, PA 19107.
Supported by the Center Grants from the Muscular Dystrophy Association and NIH (NINCDS-NS11766) and GCRC (RR-00645). Dr. Shy was a recipient of research fellowships from the NINCDS and the Muscular Dystrophy Association.
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