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NEUROLOGY 1986;36:1503
© 1986 American Academy of Neurology

Cerebrospinal fluid C9 in demyelinating disease

D.A.S. Compston, PhD, FRCP, B. P. Morgan, PhD, D. Oleesky, MB, BS, R. Fifield, PhD and A. K. Campbell, PhD

Departments of Neurology (Dr. Compston) and Medical Biochemistry (Drs. Morgan, Oleesky, Fifield, and Campbell), University of Wales College of Medicine, Heath Park, Cardiff, UK.

We measured CSF and plasma concentrations of C9, IgG, and albumin in 91 patients with demyelination and 73 controls with other neurologic diseases. The C9 index was reduced and IgG index increased in patients with multiple sclerosis and those with isolated demyelinating lesions, irrespective of disease activity; abnormalities were less marked in patients with isolated lesions than in those with MS. Humoral mechanisms may not be responsible for initiating demyelination, but activation of the complement system could amplify tissue damage and account for some symptomatic recovery.

Address correspondence and reprint requests to Dr. Compston, Department of Neurology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XW, UK.

Accepted for publication March 5, 1986.




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