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NEUROLOGY 1986;36:1521
© 1986 American Academy of Neurology

Acute effects of phenytoin on brainstem auditory evoked potentials

Clinical and experimental study

Genjiro Hirose, MD, Yoshinobu Kitagawa, MD, Tadashi Chujo, MS, Rokuhei Oda, MD, Satoshi Kataoka, MD and Matsuhei Takado, MD

Department of Neurology, Kanazawa Medical University, Uchinada, Kahoku. Ishikawa Prefecture, Japan.

In a patient with phenytoin (PHE) intoxication, the brainstem auditory evoked potentials (BAEPs) were lost except for wave I and wave V. The patient recovered. In rats given PHE, we found changes in amplitude, morphology, and latency of BAEP. Within 5 minutes, all waves disappeared except for wave I, and soon thereafter all waves were lost, with PHE plasma concentration between 45.8 and 52.1 µg/ml or above. Ninety minutes after infusion, waves gradually reappeared. Loss of BAEP cannot be used as a criterion for brain death unless PHE intoxication is ruled out.

Address correspondence and reprint requests to Dr. Hirose, Department of Neurology, Kanazawa Medical University, Uchinada, Kahoku, Ishikawa Prefecture, Japan 920-02.

Accepted for publication February 25, 1986.






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