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NEUROLOGY 1986;36:1534
© 1986 American Academy of Neurology

Serial neuropsychological studies of a child with acute lympho-blastic leukemia and subsequent glioblastoma multiforme

Raymond K. Mulhern, PhD, Abby L. Wasserman, MD, Edward H. Kovnar, MD, J. Michael Williams, PhD and Judith J. Ochs, MD

Departments of Child Health Sciences and Hematology/Oncology. St. Jude Children's Research Hospital, Memphis, TN.

A 10-year-old boy had a right posterior parietal glioblastoma 5 years after completing treatment for acute lymphoblastic leukemia. Interim findings included seizures, leukoencephalopathy, diffuse mineralizing micro-angiopathy, and abnormal changes in neuropsychological test performance, which, in retrospect, provided information about the location of the tumor. This case highlights unusual sequelae of childhood leukemia and its treatment, as well as the value of neuropsychological procedures in assessing functional status and integrity of the brain.

Address correspondence and reprint requests to Dr. Mulhern, Division of Psychiatry/Psychology. St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38101.

Accepted for publication March 12, 1986.






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