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Allopurinol and severe epilepsy

Department of Child Neurology (Dr. DeMarco), CTR "Angeli Custodi" Istituti Ospedalieri, Trento, and the Department of Neurology (Dr. Zagnoni), Ospedale S. Croce, Cuneo, Italy.

Forty-one epileptic and not hyperuricemic subjects, aged 2 to 54 years, had epileptic seizures, ranging from 1 to 220 weekly (mean = 21.3). All seizure types were represented. They were already medicated with two or three antiepileptic drugs with plasma drug concentrations maintained in therapeutic range. They were treated with allopurinol in doses ranging from 150 to 300 mg daily. After 20 to 35 days of this regimen, a progressive decrease of the weekly seizure frequency was observed in two-thirds of the cases. After a follow-up of 3 to 9 months, seizures disappeared completely (22%) or decreased more than 50% (47%). Twenty-five percent of subjects continued to have the same seizure frequency, while about 6% were worse than before.

Address correspondence and reprint requests to Dr. DeMarco, Department of Child Neurology, CTR "Angeli Custodi" Istituti Ospedalieri, Trento, Italy.

Accepted for publication March 8, 1986.