HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Creasey, H. Articles by Rapoport, S. I. Search for Related Content PubMed PubMed Citation Articles by Creasey, H. Articles by Rapoport, S. I.

Quantitative computed tomography in dementia of the Alzheimer type

Laboratory of Neurosciences (Drs. Creasey, Schwartz, Haxby, and Rapoport), National Institute on Aging, and the Division of Computer Research and Technology (Dr. Frederickson), National Institutes of Health, Bethesda, MD.

Men and women with dementia of the Alzheimer type (DAT) had more brain atrophy and ventricular dilatation, measured by quantitative CT, than did respective age- and sex-matched healthy controls (p < 0.05). The male DAT patients with mild dementia had a larger mean third ventricle volume, whereas male patients with severe dementia had larger lateral and third ventricle volumes, more CSF, and less gray matter than did controls. Statistically significant and appropriate correlations between several dementia scales and CT measures in the DAT patients indicated that brain atrophy and ventricular dilatation were related to the severity of dementia.

Address correspondence and reprint requests to Dr. Rapoport, Building 10, Room 6C103, NIH, Bethesda, MD 20892.

Accepted for publication March 24, 1986.

This article has been cited by other articles:

				N. Kemppainen, H. Ruottinen, K. Nagren, and J. O. Rinne PET shows that striatal dopamine D1 and D2 receptors are differentially affected in AD Neurology, July 25, 2000; 55(2): 205 - 209. [Abstract] [Full Text] [PDF]

				R. Fama, E. V. Sullivan, P. K. Shear, L. Marsh, J. A. Yesavage, J. R. Tinklenberg, K. O. Lim, and A. Pfefferbaum Selective Cortical and Hippocampal Volume Correlates of Mattis Dementia Rating Scale in Alzheimer Disease Arch Neurol, June 1, 1997; 54(6): 719 - 728. [Abstract] [PDF]

				C.-A. Cuenod, A. Denys, J.-L. Michot, P. Jehenson, F. Forette, D. Kaplan, A. Syrota, and F. Boller Amygdala Atrophy in Alzheimer's Disease: An In Vivo Magnetic Resonance Imaging Study Arch Neurol, September 1, 1993; 50(9): 941 - 945. [Abstract] [PDF]

				E. V. Sullivan, P. K. Shear, D. H. Mathalon, K. O. Lim, J. A. Yesavage, J. R. Tinklenberg, and A. Pfefferbaum Greater Abnormalities of Brain Cerebrospinal Fluid Volumes in Younger Than in Older Patients With Alzheimer's Disease Arch Neurol, April 1, 1993; 50(4): 359 - 373. [Abstract] [PDF]

				A. Kumar, M. B. Schapiro, C. L. Grady, M. F. Matocha, J. V. Haxby, A. M. Moore, J. S. Luxenberg, P. H. S. George-Hyslop, C. D. Robinette, M. J. Ball, et al. Anatomic, Metabolic, Neuropsychological, and Molecular Genetic Studies of Three Pairs of Identical Twins Discordant for Dementia of the Alzheimer's Type Arch Neurol, February 1, 1991; 48(2): 160 - 168. [Abstract] [PDF]

				C. L. Grady, A. M. Grimes, N. Patronas, T. Sunderland, N. L. Foster, and S. I. Rapoport Divided Attention, as Measured by Dichotic Speech Performance, in Dementia of the Alzheimer Type Arch Neurol, March 1, 1989; 46(3): 317 - 320. [Abstract] [PDF]

				R. P. Friedland, E. Koss, J. V. Haxby, C. L. Grady, J. Luxenberg, M. B. Schapiro, and J. Kaye Alzheimer Disease: Clinical and Biological Heterogeneity Ann Intern Med, August 15, 1988; 109(4): 298 - 311. [Abstract] [PDF]

				J. Aharon-Peretz, J. L. Cummings, and M. A. Hill Vascular Dementia and Dementia of the Alzheimer Type: Cognition, Ventricular Size, and Leuko-Araiosis Arch Neurol, July 1, 1988; 45(7): 719 - 721. [Abstract] [PDF]