HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hauser, S. L. Articles by Henderson, C. E. Search for Related Content PubMed PubMed Citation Articles by Hauser, S. L. Articles by Henderson, C. E.

Immunoblot analysis of circulating antibodies against muscle proteins in amyotrophic lateral sclerosis and other neurologic diseases

Unités d'Immunochimie Analytique and Neurobiolugie Moléculaire, Institut Pasteur, and the Hôpital Salpétrière, Paris, France.

Serum from patients with amyotrophic lateral sclerosis (ALS) was tested by immunoblotting for reactivity against three muscle-derived preparations: denervated chick leg muscle extracts, media conditioned by denervated rat hemidiaphragms, and a human muscle extract. For each preparation, multiple bands were present using serum from all patients and controls, and no band was unique to ALS. Against rat muscle-conditioned medium, bands in the 56,000 (56K) molecular weight range were present to an equal degree in ALS and in controls; in addition, different bands near 56K were recognized by serum from different ALS patients. These results fail to confirm a recent report suggesting that anti-56K reactivity is characteristic of ALS.

Address correspondence and reprint requests to Dr. Mauser, Department of Neurology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114.

Dr. Mauser is a fellow of the Moseley Foundation of Harvard University.

Accepted for publication March 26, 1986.