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Department of Neurology, The College of Physicians and Surgeons, Columbia University, New York, NY; and the University Department of Neurology, Institute of Psychiatry and King's College Hospital Medical School, London, England.
We studied trihexyphenidyl in the treatment of torsion dystonia in a prospective, double-blind crossover protocol. Thirty-one patients completed the protocol. Twenty-two (71%) had a clinically significant response. After a mean follow-up of 2.4 years, 68% of patients continued to take trihexyphenidyl, and 42% continued to show a considerable or dramatic benefit. The 30-mg dose used was generally well tolerated. High-dosage trihexyphenidyl therapy is effective in the management of torsion dystonia.
Address correspondence and reprint requests to Dr. Burke, Neurological Institute, 710 W. 168th Street, New York, NY 10032.
Supported by the Dystonia Medical Research Foundation. In New York, this study was conducted at the Dystonia Clinical Research Center at Columbia University. R.E.B. is the recipient of an NINCDS Teacher-Investigator Award (#1 Ko7 NS00748–01A1).
Accepted for publication June 4, 1985.
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