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Neurotransmitter receptors in olivopontocerebellar atrophy

An autoradiographic study

Departments of Neurology and Neuroscience (Dr. Whitehouse) and Pathology and Neurology (Dr. Troncoso), The Johns Hopkins University School of Medicine, Baltimore, MD; and the Department of Neurology (Drs. Muramoto and Kanazawa), University of Tsukuba, Japan.

We used in vitro receptor autoradiography to study four cases of olivopontocerebellar atrophy (OPCA) and three age-and postmortem delay-matched controls. In OPCA, benzodiazepine receptors were unchanged in cerebellar cortex but increased in the dentate nucleus, perhaps related to loss of Purkinje cell or brainstem afferents. Muscimol binding was reduced primarily in the granule cell layer. The density of muscarinic cholinergic receptors was reduced in molecular and granule cell layers, but appeared increased in the dentate.

Address correspondence and reprint requests to Dr. Whitehouse, 509 Pathology Building, The Johns Hopkins University School of Medicine, Neuropathology Laboratory, 600 N. Wolfe Street, Baltimore, MD 21205–2182.

Support from the McKnight, Sloan and Commonwealth Foundations, as well as NS 15080 and MH 25951 is appreciated.

Accepted for publication May 30, 1985.

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