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Serum-mediated oligodendrocyte cytotoxicity in multiple sclerosis patients and controls

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA.

We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding a source of complement. Despite apparent lack of disease specificity, such factors might damage oligodendrocytes if they gained access to these cells through a damaged blood-brain barrier in MS or other disorders.

Address correspondence and reprint requests to Dr. Lisak, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

Supported by grants from NIH (NS 11037) and the National Multiple Sclerosis Society of the United States of America.

Accepted for publication June 18, 1985.

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