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NEUROLOGY 1986;36:284
© 1986 American Academy of Neurology

A case-control study of twin pairs discordant for Parkinson's disease

A search for environmental risk factors

Nadir E. Bharucha, MD, FRCP(C), Lynette Stokes, MPH, Bruce S. Schoenberg, MD, DrPH, Christopher Ward, MD, Susan Ince, MS, John G. Nutt, MD, Roswell Eldridge, MD, Donald B. Calne, MD, Nathan Mantel, MA and Roger Duvoisin, MD

Neuroepidemiology Branch, Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke (Dr. Bharucha, Ms. Stokes, Drs. Schoenberg and Ward, Ms. Ince, and Dr. Eldridge), Bethesda, MD; Oregon Health Sciences University (Dr. Nutt), Portland, OR; Division of Neurology, Department of Medicine (Dr. Calne), University of British Columbia, Vancouver, Canada; Department of Mathematics, Statistics and Computer Science (Mr. Mantel), The American University, Washington, DC; and the Department of Neurology (Dr. Duvoisin), UMDNJ, Rutgers Medical School, Piscataway, NJ.

A previous study of twins with Parkinson's disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p < 0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.

Address correspondence and reprint requests to Dr. Schoenberg, NINCDS, NIH, Federal Building, Room 804, 7550 Wisconsin Avenue, Bethesda, MD 20892.

Mr. Nathan Mantel's work was supported by a USPHS Grant CA34096 from the National Cancer Institute.

Accepted for publication May 30, 1985.




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