HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Brooke, M. H. Articles by Kaiser, K. K. Search for Related Content PubMed PubMed Citation Articles by Brooke, M. H. Articles by Kaiser, K. K.

Inosine monophosphate production is proportional to muscle force in vitro

Washington University Medical School, Department of Neurology, St. Louis, MO.

An in vitro system of muscle stimulation has been developed that combines physiologic measurements with biochemical evaluation. In the rat epitrochlearis muscle, 2 minutes of stimulation at 4 Hz results in a marked elevation of inosine monophosphate (IMP) levels. The amount of IMP generated is proportional to the amount of force developed. Depriving the muscle of oxygen results in an increased amount of IMP generation. This model provides direct confirmation of similar findings in the human forearm exercise test.

Address correspondence and reprint requests to Dr. Brooke, Washington University Medical School, Department of Neurology, 660 South Euclid, Box 8111, St. Louis, MO 63110.

Supported by a grant from the Muscular Dystrophy Association.

Accepted for publication May 30, 1985.