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CSF somatostatin-like immunoreactivity in dementia

Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA.

Concentrations of somatostatin-like immunoreactivity (SLI) in CSF were reduced in Alzheimer's disease (AD) and multi-infarct dementia (p < 0.01), but not in normal-pressure hydrocephalus, Parkinson's disease, and Huntington's disease. This suggests that reduced SLI content in AD cerebral cortex is reflected in CSF. Chromatographic characterization of CSF SLI showed no differences between AD and controls. Concentrations of SLI in AD patients overlapped those in both normal subjects and patients with multi-infarct dementia, so that changes in CSF SLI have no diagnostic specificity.

Address correspondence and reprint requests to Dr. Beal, Neurology Research, Research 4, Massachusetts General Hospital, Boston, MA 02114.

Supported by the Huntington's Disease Center Without Walls (National Institute of Health Grant NS16367), the Julieanne Dorn Fund, and Alzheimer's Disease Research Center Grant; NIA P50AG051134. Dr. Beal is a fellow of the National Huntington's Disease Association and holds a Young Investigator Award 1R23NS19867–1. Dr. Mazurek is a Fellow of the Medical Research Council of Canada.

Presented in part at the thirty-fifth annual meeting of the American Academy of Neurology, Boston, MA, April 1983.

Accepted for publication May 30, 1985.

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