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NEUROLOGY 1986;36:297
© 1986 American Academy of Neurology

Target fibers in multiple sclerosis

Implications for pathogenesis

Jack E. Riggs, MD, Sydney S. Schochet, Jr, MD, Thomas A. Kopitnik, MD and Ludwig Gutmann, MD

Departments of Neurology (Drs. Riggs and Gutmann), Pathology (Dr. Schochet), and Neurosurgery (Dr. Kopitnik), West Virginia University School of Medicine, Morgantown, WV.

Target fibers are generally considered a specific indicator of denervating disease. We found large numbers of target fibers in a biceps biopsy from a patient with MS and spastic quadriparesis. There was no evidence of denervation. Target fibers are not seen only in denervation.

Address correspondence and reprint requests to Dr. Riggs, Department of Neurology, West Virginia University Medical Center, Morgantown, WV 26506.

Accepted for publication June 3, 1985.






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