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Facial clefts in sibs and children of epileptic patients

Departments of Neurology (Dr. Friis), Hvidovre and Gentofte Hospitals, University of Copenhagen; Institute of Clinical Genetics (Drs. Holm and Hauge), University of Odense, and Department of Clinical Neurophysiology (Dr. Sindrup), Odense University Hospital, Odense; and the Department of Plastic Surgery (Dr. Fogh-Andersen), Deaconess Hospital, Copenhagen, Denmark.

The prevalence of facial clefts in sibs and children of 2,072 epileptics ascertained in a defined region was determined by record linkage with a national cleft register, which also provided expected figures. Observed/expected ratios were increased only for cleft lip with or without cleft palate if the mother had manifested epilepsy: it was 4.7 when anticonvulsants were given before and during pregnancy, 2.7 in cases with no treatment, and zero in children born prior to maternal epilepsy. Children of epileptic men and sibs of epileptics showed no increase. The prevalence of isolated cleft palate was not above expectation in any group.

Address correspondence and reprint requests to Dr. Friis, Department of Neurology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark.

Supported by Danish Medical Research Council grants 512–8907, 512–15005, and 12–2839.

Accepted for publication July 26, 1985.

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