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NEUROLOGY 1986;36:351
© 1986 American Academy of Neurology

Effects of valproate on biogenesis and function of liver mitochondria

Kiyoshi Hayasaka, MD, Iku Takahashi, MD, Yasuko Kobayashi, MD, Kazuie Iinuma, MD, Kuniaki Narisawa, MD and Keiya Tada, MD

Departments of Pediatrics (Drs. Hayasaka, Takahashi, linuma, Narisawa, and Tada) and Anatomy (Dr. Kobayashi), Tohoku University School of Medicine, Sendai, Japan.

The mitochondrial protein content of liver increased, and mitochondria enlarged after prolonged administration of valproic acid (VPA: N-dipropylacetic acid) to rats. The mitochondria showed low specific activities of membrane-bound enzymes, decreased content of cytochrome aa3, and decreased respiration in states 3 and 4. In vitro studies of amino acid incorporation suggested a decrease in protein synthesis in liver mitochondria from VPA-treated rats. Prolonged administration of VPA seems to impair mitochondrial structure and function.

Address correspondence and reprint requests to Dr. Hayasaka, Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Sendai 980, Japan.

Accepted for publication July 26, 1985.




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