HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Tsementzis, S. A. Articles by Beevers, D. G. Search for Related Content PubMed PubMed Citation Articles by Tsementzis, S. A. Articles by Beevers, D. G.

Oligoclonal immunoglobulin G in acute subarachnoid hemorrhage and stroke

Departments of Neurosurgery (Drs. Tsementzis, Chao, and Hitchcock) and Medicine (Drs. Gill and Beevers), Dudley Road Hospital, University of Birmingham, UK.

Oligoclonal Ig bands were found in serum and CSF of 13 of 83 patients (16%) with verified subarachnoid hemorrhage (SAH). Serum Ig bands were more common in patients with SAH than in those with cerebral ischemia. The reverse was true with oligoclonal Ig bands in CSF. These patterns suggest that there are two different mechanisms and sites of IgG synthesis: an inflammatory process after acute stage of vascular damage and a latent immunologic process—ie, polyclonal B-cell activation by injury to the brain.

Address correspondence and reprint requests to Dr. Tsementzis, Midland Centre for Neurosurgery and Neurology, Holly Lane, Smethwick, Warley, West Midlands B67 7JX, England.

Supported by research funds from the Department of Neurosurgery, University of Birmingham, and the West Midlands Regional Health Authority.

Accepted for publication July 26, 1985.