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Bromocriptine holiday

Effects on dopamine receptors and turning behavior in rats

Departments of Neurology and Pharmacology, University of Nebraska Medical Center, Omaha, NE.

In experimental Parkinson's disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphine-induced contralateral turning produced by the lesion was unaffected by any drug regimen.

Address correspondence and reprint requests to Dr. Pfeiffer, Department of Neurology, University of Nebraska Medical Center, 42nd and Dewey Avenue, Omaha, NE 68105.

Supported by the Frances and Edgar Reynolds Foundation and by a research fellowship from the Nebraska Medical Foundation (to A.M.K.).

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, May 1985.

Accepted for publication July 26, 1985.