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NEUROLOGY 1986;36:411
© 1986 American Academy of Neurology

Sleep EEG in Korsakoff's psychosis and Alzheimer's disease

Peter R. Martin, MD, FRCP (C), Richard J. Loewenstein, MD, Walter H. Kaye, MD, Michael H. Ebert, MD, Herbert Weingartner, PhD and J. Christian Gillin, MD

Laboratory of Clinical Studies (Dr. Martin), DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD; the Department of Psychiatry and Biobehavioral Science (Dr. Loewenstein), UCLA School of Medicine, Los Angeles, CA; the Laboratory of Psychology and Psychopathology (Drs. Kaye and Weingartner), National Institute of Mental Health, Bethesda, MD; the Department of Psychiatry (Dr. Ebert), Vanderbilt University, Nashville, TN; and the Department of Psychiatry (Dr. Gillin), UCSD, San Diego, CA.

All-night sleep EEGs were compared in the following age-equivalent groups: seven men with Korsakoff's psychosis (KP), six men and two women with presumptive Alzheimer's disease, and six healthy men and three healthy women. KP patients had significantly increased intermittent time awake than both controls and Alzheimer patients, and shorter REM latency minus time awake than controls. Alzheimer patients had significantly reduced delta sleep than controls. Differences in the pattern of sleep EEG abnormalities may be due to different pathogenic mechanisms, but their utility in differential diagnosis requires further study.

Address correspondence and reprint requests to Dr. Martin, National Institutes of Health, Building 10, Room 3B-19, 9000 Rockville Pike, Bethesda, MD 20205.

Accepted for publication August 5, 1985.




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