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NEUROLOGY 1986;36:581-584
© 1986 American Academy of Neurology

ARTICLES

Genetic linkage studies in Alzheimer's disease

MA Spence, A Heyman, ML Marazita, RS Sparkes and T Weinberg

We studied 18 families with Alzheimer's disease in family members, under the assumption that the disease is due to a single gene with an autosomal dominant form of inheritance. There was no evidence of linkage of Alzheimer's disease with any of 27 phenotypic gene markers analyzed, but close linkage for the Rh and MNS blood group loci was excluded.


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