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NEUROLOGY 1986;36:602
© 1986 American Academy of Neurology

Prognostic factors in brainstem gliomas

Michael E. Cohen, MD, Patricia K. Duffner, MD, Reid R. Heffner, MD, Daniel J. Lacey, MD, PhD and Martin Brecher, MD

State University of New York at Buffalo. School of Medicine. Buffalo. NY.

Although brainstem gliomas carry the worst prognosis of any brain tumor in children, with median survivals of 9 to 12 months, there may be a subgroup of long-term survivors. We have identified 12 children with brainstem gliomas, 5 of whom have survived > 6 years and 6 ≤ 12 months. Another child, alive and well 3 years following diagnosis, was considered in the long-term survivor group. Favorable prognostic factors included neurofibromatosis, symptoms ≥ 12 months before diagnosis, calcification on CT, exophytic location, and pathology suggesting a low-grade tumor. Recognition that certain patients with brainstem gliomas may have prolonged survivals even in the absence of definitive treatment must be taken into consideration when new treatment regimens are being formulated.

Address correspondence and reprint requests to Dr. Cohen. Department of Neurology. Children's Hospital. 219 Bryant Street. Buffalo. NY 14222.

Accepted fur publication October 14. 1985.




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