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NEUROLOGY 1986;36:612
© 1986 American Academy of Neurology

Myasthenia gravis

Monoclonal antihuman acetylcholine receptor antibodies used to analyze antibody specificities and responses to treatment

Paul J. Whiting, Angela Vincent and John Newsom-Davis

Department of Neurological Science, Royal Free Hospital School of Medicine, London.

We investigated the heterogeneity of serum antibodies to acetylcholine receptor (AChR) by competition with nine antihuman monoclonal antibodies in a cross-sectional study of 36 patients with myasthenia gravis (MG), and in three who showed clinical improvement associated with decrease in total anti-AChR following immunologic treatment. Two specificities were more prevalent in patients without thymoma, and one of these was more prevalent in cases beginning before age 40. Some specificities were stable during serial studies, whereas others fluctuated. We found evidence of three groups of antibody specificities that had different control mechanisms and may define different regions of the receptor.

Address correspondence and reprint requests to Dr. Vincent, Department of Neurological Science, Royal Free Hospital School of Medicine. Rowland Hill Street, London NW3 2PF. England.

Supported by the Medical Research Council. P.J.W. held an MRC studentship.

Accepted for publication October 1, 1985.




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[Abstract] [PDF]


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