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The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies

Department of Chemical Immunology, The Weizmann Institute of Science. Rehovot, Israel.

Experimental autoimmune myasthenia gravis (EAMG) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding site of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.

Address correspondence and reprint requests to Dr. Fuchs, Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.

Supported in part by the Muscular Dystrophy Association of America, the Los Angeles Chapter of the Myasthenia Gravis Foundation, and the United States-Israel Binational Science Foundation (BSF).

Accepted for publication October 10, 1985.