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PET studies of cerebral glucose metabolism in idiopathic torticollis

Division of Neurology, Department of Medicine (Drs. Stoessl, Martin, Beckman, and Calne), and Department of Psychiatry (Dr. Clark), U.B.C. Health Sciences Centre Hospital; and UBC/TRIUMF PET Program (Drs. Adam, Ammann, Bergstrom. Harrop, Rogers, Ruth, Sayre, and Pate), University of British Columbia, Vancouver, British Columbia, Canada.

Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the thalamus and basal ganglia. The findings suggest disruption of the pallidothalamic projections in this focal dystonia and may imply a disturbance of GABA.

Address correspondence and reprint requests to Dr. Stoessl, Division of Neurology, Department of Medicine, U.B.C. Health Sciences Centre Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia, V6T 1W5, Canada.

Supported in part by the Dystonia Medical Research Foundation and the Medical Research Council of Canada.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Accepted for publication October 1, 1985.

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